Sounds like a bad install? maybe try starting over for the game itself...?
I'm not a huge fan of the AMD cards lately they're so unreliable, my 5700xt I purchased a couple years ago seems to konk out when it hasn't been warmed up.
For the record I can run it on my 5700xt in 4k on high (haven't tried ultra yet) with no issue or dropped rates.
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